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Can finding humor in our darkest moments actually help us heal? Comedian and entrepreneur Natasha Pearl Hansen believes the answer is yes—and she has the stories to prove it.

Astronomer Wendy Freedman, at the University of Chicago, shares humanity's quest to measure the expanding universe, revealing an exciting scientific mystery: our measurements don't match.

In this emotional and forward-thinking talk, Dr. Hossein Zargartalebi shares his deeply personal journey from a hospital room to a scientific breakthrough. His innovation—a molecular sensor that detects proteins in real time—may unlock a new era in healthcare, one where disease can be caught long before symptoms appear. By turning biology’s quietest signals into a clear voice, this technology gives us something medicine has never truly had before: the ability to act early, save lives, and give people back the most precious thing of all—time.

Most people think great and long lasting relationships are built on chemistry — but the real magic lies in communication. In this talk, Dr. Hareder McDowell explores how the way we defeat our silence, begin to speak, listen, and connect directly, shapes emotional intimacy, trust, and even physical desire. Drawing from research and real-life stories, Dr. Mac reveals how mastering communication doesn’t just improve relationships and sex — it transforms them. Because you have the power to talk you way to better sex.

We are what we do — our identities are the sum of our knowledge, experiences and actions. In a world rapidly filled with AI generators, what does it take to protect our identity, and those of the generations to come? Heather Zheng, co-director of the SANDLAB at UChicago, presents bold ideas that empower individuals to restore control over their identity by changing how they share data online. Together with her partner, Ben Zhao, the two UChicago professors and their team have released Glaze and Nightshade, tools that disrupt generative AI from training on and mimicking artists without their consent.

Physicist David Awschalom takes us on a fast-paced journey from Star Trek to quantum teleportation, showing how what once seemed like science fiction is quickly becoming reality. Equal parts inspiring and mind-bending, he reveals how uncertainty—the quirky heart of quantum physics—is actually a powerful engine of discovery, fueling breakthroughs in computing, medicine, and secure communication. This talk makes clear that our quantum future is not just coming—it’s already here.

Alessandro F. Rotta Loria’s talk delivers an intense emotional and intellectual experience about the urban underground, unveiling a silent threat that simultaneously represents a massive opportunity for the clean energy transition of cities, before we run out of time.

Dr. Shana Kelley leads a team of human cell hunters, and they developed a unique and highly sensitive cell processor that can pull incredibly rare, disease-fighting cells out of blood. Recently, they used the device to search for immune cells that can fight cancer, and uncovered surprising and exciting results that may have immense impact on the future of cancer. Join Dr. Shana Kelley as she brings you on a journey through discovery, learn a little bit about immunotherapy, and get excited about what the next era of cancer treatments may look like. A talk to find hope from, and to share and view with those in your life affected by cancer.

Dr. Shirley Meng makes the case for hope by demonstrating some of the exciting technologies and new batteries her lab is developing that could close the energy storage gap we need to create a democratization of energy that also enables a fully renewable energy grid.

At a time when we’re at our most divided, maybe the surprising answer to bringing us all together can be found through sports. In the midst of a loneliness epidemic, AJ Maestas, the Founder of Navigate, explores his own relationship with sports and how it made him a part of something greater than he could have expected when he left Fairbanks, Alaska at age 18. Whether you love football (in the American or global sense), baseball, Taylor Swift, or even if you don’t consider yourself a sports or entertainment fan at all, this talk offers an emotional and engaging look at why the fans in your life act the way they do. Our fundamental need for belonging drives us to find community and shared passion for sports, music, or the many other reasons we gather.

James Evans asks a critical question as we ponder our AI-driven future: "What AI do we deserve?" He then takes us on a journey making the case that alien intelligence and thus alien AI that we grow and care for will be the most impactful on us as a human society. On the way, he also outlines the surprising science behind his lab's AI models and algorithms: That diversity is at the heart of the greatest scientific discoveries.

Michael Jewett is a bioengineer who wonders if we can create equitable and distributed biotechnologies for the good. In this thought-provoking and insightful talk, he lays out a vision to re-think how biotechnologies are created and shared, made possible by biology without cells. Can just-add-water biotechnology turn us all into biomakers? Listen and learn how engineered biological systems are opening access to medicines, diagnostics, and more.

Jane lost her husband at the age of 47. This experience transformed every aspect of her life. She believes this level of transformation is available to every single person out there. When we don't talk about death and remind ourselves daily, (maybe hourly) that we are going to die, we run the risk of taking this magical gift called life for granted and getting all tangled up in caring about what doesn't matter.

Child welfare veteran Amelia Franck Meyer describes the human need to belong and to be claimed. When we are disconnected from our tribe, and we feel as though we must make it on our own, it can have devastating life-long impacts. Listen to Amelia share the profound power of human connection.